university of calcutta

Arghya Adhikary

DST INSPIRE Faculty, Assistant Professor

Address

  • Centre for Research in Nanoscience and Nanotechnology,
  • University of Calcutta,
  • JD-2, Sector-III, Salt Lake,
  • Kolkata, West Bengal, 700106, INDIA

adhikaryarghya@gmail.com

RESEARCH INTEREST

  • We are interested in studying Signaling pathways associated with Cancer cell metastasis and apoptosis, deciphering the role of different miRNA signatures in cancer metastasis and apoptosis, elucidation of the role of the miRNA axis in development of cancer stem cells required for maintenance and metastasis of cancer. We are also studying cancer nano-therapeutics: Design, development, characterization and application of different polymeric, metallic and nonmetallic nano-particles in cancer regression, synthesis and application of targeted nano delivery system loaded with anticancer drug as well as miRNAs, development of improved targeted nano-therapeutics against cancer stem cells.

Profile

Education

  • Ph.D., Jadavpur University, Kolkata, India
    Work pursued at Bose Institute, Kolkata
  • M.Sc., University of Kalyani, Kalyani, Nadia, India
  • B.Sc., Hooghly Mohsin College, Burdwan University. West Bengal, India

Professional Experience

  • DST INSPIRE Faculty, Assistant Professor, Centre for Research in Nanoscience and Nanotechnology (CRNN), University of Calcutta

Awards and Fellowships

  • Received ‘Sir Nilratan Sircar award for the best P.hD student of the year’ of Bose Institute in the year 2011.
  • Received the CSIR-RA award from CSIR on January 2013.
  • Received the DST INSPIRE Faculty award from DST on February 2013.
  • Received the International Travel Grant form ICMR for non ICMR scientists to attend the “World Breast Cancer Conference” at Birmingham, UK in August 2015.
  • Designated among the ten (10) most innovative scientist in India in ‘Bio Asia Drug Discovery and Innovation Award Programme -2016’ at Hyderabad Tech Conference during February 8-10, 2016.

Projects

S. No. Title of the Project(s) Sponsoring Agency Period Amount Status
1. Targeting p53/p63-miRNA axis to regulate integrin recycling on the membrane: An approach to control the migration of highly metastatic p53-mutated breast cancer cells
Investigators Name:- Dr. Arghya Adhikary 		DST INSPIRE 5 years
Date of Start: 10.04.2013		 Rs 35,00,000/- Ongoing
2. Synthesis of amine functionalized mesoporous silica nanoparticles for delivery of miRNA to cancer cells to restrict cancer metastasis
Investigators Name:- Dr. Arghya Adhikary 		Centre for Research in Nanoscience and Nanotechnology (CRNN), University of Calcutta,  Seed Funding. 2 years
Date of start:- 19.06.2014		 2,00,000/- + Fellowship of a JRF/SRF for 3 years. Completed
3. Evaluation of the involvement of mir205 in integrin recycling on the membrane and therapeutic delivery of miRNA by nanoparticles to control metastasis of p53-mutated breast cancer.
Investigators Name:- Dr. Arghya Adhikary.		 DBT 3 years
Date of start:- 29.07.2015		 25,10,000/- Ongoing
4. Exploration of the therapeutic potential of hyaluronic acid decorated different graphene based nano materials for targeting cancer stem cells: A novel approach aiding cancer therapy.
Investigators Name:- Dr. Dipankar Chattopadhyay.
CO-Investigators Name:- Dr. Arghya Adhikary.		 DBT Nanobiotechnology 1year
Date of start:- 23.06.2016		 Rs 10,60,000/- Completed
5. A therapeutic approach of targeted delivery of miRNAs through nanoparticles to control metastasis of Triple Negative Breast cancer in-vitro and in-vivo.
Investigators Name:- Dr. Arghya Adhikary.		 DST Nanomission. 3 years
Date of start:- January 2017.		 Rs 49,97,000/- Ongoing
6. Anti-migratory role of black seed extract (thymoquinone) nanoparticle in triple negative breast cancer cells: Evaluation of Molecular mechanisms via miRNA axis
Investigators Name:- Dr. Arghya Adhikary.		 Ministry of AYUSH. 3 years
Date of start:- February 2017.		 Rs 35,36,890/- Ongoing

Publications

2019

  1. Pramanik N, Bhattacharya S, Rath T, De J, Adhikary A, Basu R, Kundu P. Polyhydroxybutyrate-co-hydroxyvalerate copolymer modified graphite oxide based 3D scaffold for tissue engineering application. Materials Science & Engineering C (2019). (Impact Factor. 5.08).
  2. Mahiuddin M, Banerjee M, Shaikh A, Shyam T, Taniya S, Ghosh A, Adhikary A, Brandão P, Félix V, Das D. Optical sensors for detection of nano-molar Zn2+ in aqueous medium: Direct evidence of probe- Zn2+ binding by single crystal X-ray structures. Journal of Photochemistry & Photobiology A: Chemistry (2019). 52–61. (Impact Factor. 2.891)

2018

  1. Adhikari S, Ta S, Ghosh A, Guria S, Pal A, Ahir M, Adhikary A, Hirad S, Manna P, Das D. A 1,8 Naphthalimide anchor Rhodamine B Based FRET Probe for Ratiometric Detection of Cr3+ion in Living Cells. Journal of Photochemistry and Photobiology A: Chemistry (2018). doi.org/10.1016/j.jphotochem.2018.12.010.
  2. Basu A, Upadhyay P, Ghosh A, Chattopadhyay D, Adhikary A*. Folic-Acid-Adorned PEGylated Graphene Oxide Interferes with the Cell Migration of Triple Negative Breast Cancer Cell Line, MDAMB231 by Targeting miR-21/PTEN Axis through NFκB. ACS Biomaterials Science & Engineering (2018). (Impact Factor. 4.432). * Corresponding author as PI.
  3. Debnath G, Bhattacharya S, Adhikary A, Mukherjee P. Host-sensitized sharp samarium emission from doped titanium dioxide nanoparticles as non-cytotoxic photostable reporters for live-cell imaging. New Journal of Chemistry (2018). (Impact Factor. 3.201).
  4. Roy A, Sarker S, Upadhyay P, Pal A. Adhikary A, Jana K, Ray M. Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness. Biochemical Pharmacology (2018).Volume 156, Pages 322-33. (Impact Factor. 4.235).
  5. Adhikari S, Mandal S, Ghosh A, Guria S, Pal A, Adhikary A, Das D. A FRET based colorimetric and fluorescence probe for selective detection of Bi3+ ion and live cell imaging. Journal of Photochemistry and Photobiology A: Chemistry (2018). (Impact Factor. 2.891).
  6. Jana D, Bandyopadhyay S, Upadhyay P, Adhikary A, Manna A. Role Of P65 And P53 Expression In Different Stage And Grade Of Ovarian Cancer. Indian Journal of Applied Research (2018). (Impact Factor. 2.1652 ) Citation: 0 S. No. 253 (Impact Factor. 5.397)

2017

  1. Bandyopadhyay S, Upadhyay P, Adhikary A. Can Mir-34A Expression Is A Prognostic Marker In Different Stage Of Ovarian Cancer? Journal of Cancer Research & Therapeutics (2017) Vol. 13, pS152-S152. 1/5p. (Impact Factor. 0.791)
  2. Das U, Sengupta A, Biswas S, Adhikary A, Dey Sharma R, Chakraborty A, Dey S. Alteration of murine duodenal morphology and redox signaling events by reactive oxygen species generated after whole body γ-irradiation and its prevention by ferulic acid. Free Radical Research (2017); Nov 3:1-25. Doi: 10.1080/10715762.2017.1388916. [Epub ahead of print] (Impact Factor. 3.188)
  3. Sinha A, Banerjee K, Banerjee A, Sarkar A, Ahir M, Adhikary A, Chatterjee M, Choudhuri SK. Induction of apoptosis in human colorectal cancer cell line, HCT-116 by a vanadium- Schiff base complex. Biomedicine and Pharmacotherapy (2017); 92:509-518. doi: 10.1016/j.biopha.2017.05.108. [Epub ahead of print] (Impact Factor. 2.326)
  4. Roy A, Ahir M, Bhattacharya S, Parida PK, Adhikary A, Jana K, Ray M. Induction of mitochondrial apoptotic pathway in triple negative breast carcinoma cells by methylglyoxal via generation of reactive oxygen species. Molecular Carcinogenesis (2017) DOI: 10.1002/mc.22665 (Impact Factor. 4.722)
  5. Chakraborti S, Chakraborty S, Saha S, Manna A, Banerjee S, Adhikary A, Sarwar S, Hazra TK , Das T, Chakrabarti P. PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2. Free Radical Biology and Medicine (2017) https://doi.org/10.1016/j.freeradbiomed.2016.11.048 (Impact Factor. 5.736)

2015 - 2016

  1. Choudhury S, Ghosh S, Mukherjee S, Gupta P, Bhattacharya S, Adhikary A, Chattopadhyay S,, Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells. The Journal of Nutritional Biochemistry(2016) DOI: 10.1016/j.jnutbio.2016.09.001(Impact Factor. 4.662)
  2. Ray P, Guha D, Chakraborty J, Banerjee S, Adhikary A, Chakraborty S, Das T. & Sa G. Crocetin exploits p53-induced death domain (PIDD) and FASassociated death domain (FADD) proteins to induce apoptosis in colorectal cancer. Scientific Reports (2016), DOI: 10.1038/srep32979 (Impact Factor. 5.578)
  3. Chakraborty S, Ghosh S, Banerjee B, Santra A, Bhat J, Adhikary A, Chatterjee S, et al. Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signalling pathways for induction of apoptosis in human breast carcinoma cells. Apoptosis (2016), DOI 10.1007/s10495-016-1268-8 (Impact Factor. 3.592)
  4. Chakraborty A, Debnath G H, Ahir M, Bhattacharya S, Upadhyay P, Adhikary A* and Mukherjee P*, Towards the Realization of Luminescence from Visible Emitting Trivalent Lanthanides (Sm, Eu, Tb, Dy) in Polar Zinc Sulfide Nanoparticles: Evaluation of In Vitro Cytotoxicity. RSC Adv, (2016) DOI: 10.1039/C6RA03401B (Impact Factor. 3.84)
    * Corresponding author as PI.
  5. Chakraborty S, Ghosh S, Banerjee B, Santra A, Adhikary A, Misra AK and Sen PC. Phemindole, a synthetic di-indole derivative maneuvers the store operated calcium entry (SOCE) to induce potent anti-carcinogenic activity in human triple negative breast cancer cells Front. Pharmacol (2016), doi: 10.3389/fphar.2016.00114 (Impact Factor. 3.802)
  6. Mukherjee SH, Manna A, Bhattacharjee P, Mazumdar M, Saha S, Chakraborty S, Guha D, Adhikary A, Jana D, Gorain M, Mukherjee SA, Kundu GC, Sarkar DK and Das T. Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4+ migrating cancer stem cells Oncogene (2016), 1–12. doi:10.1038/onc.2016.26 In press (Impact Factor. 8.459)
  7. Ahir M, Bhattacharya S, Karmakar S, Mukhopadhyay A, Mukherjee M, Ghosh S , Chattopadhyay S, Patra P, Adhikary A*. Tailored-CuO-Nanowire decorated with Folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells. Biomaterials (2016) 76: 115-132 (Impact Factor. 8.557)
    * Corresponding author as PI.
  8. Sardar D, Neogi S. K, Bandyopadhyay S, Satpati B, Ahir A, Adhikary A, Jain R, Gopinath C S., Bala T, Multifaceted core–shell nanoparticles: superparamagnetism and biocompatibility New J. Chem (2015) DOI: 10.1039/C5NJ01481F. (Impact Factor. 3.086)
  9. Mukherjee S, Ghosh S, Das DK, Chakraborty P, Choudhury S, Gupta P, Adhikary A, Dey S & Chattopadhyay S. Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection - synthesis, characterization and in vitro evaluation, J Nutr Biochem (2015) 27(7):1398 (Impact Factor. 4.552)
  10. Patra P, Mitra S, Das Gupta, A, Pradhan S, Bhattacharya S, Ahir M, Mukherjee S, Sarkar, S, Roy S, Chattopadhyay S, Adhikary A, Goswami A, Chattopadhyay D. Simple synthesis of biocompatible biotinylated porous hexagonal ZnO nanodisc for targeted doxorubicin delivery against breast cancer cell: in vitro and in vivo cytotoxic potential. Colloids and Surfaces B: Biointerfaces (2015) 133: 88–98. (Impact Factor. 4.152)
  11. Saha S, Mukherjee S, Mazumdar M, Manna A, Khan P, Adhikary A, Kajal K, Jana D, Sa G, Mukherjee S, Sarkar DK, Das T. Mithramycin A sensitizes therapy resistant breast cancer stem cells toward genotoxic drug doxorubicin. Transl Res. (2015) 165(5):558-77. (Impact Factor. 3.402)
  12. Ghosh S, Mukherjee S, Choudhury S, Gupta P, Adhikary A, Baral R, Chattopadhyay S. Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: Role of fluoxetine. Cell Signal. (2015) 27(7):1398-412. (Impact Factor. 4.315)
  13. Bhattacharya S, Ahir M, Patra P, Mukherjee M, Ghosh S, Mazumdar M, Chattopadhyay S, Das T , Chattopadhyay D, Adhikary A*. PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a. Biomaterials (2015) 51:91-107. (Impact Factor. 8.557)
    * Corresponding author as PI.
  14. Ghosh S, Adhikary A, Chakraborty S, Bhattacharjee P, Mazumdar M, Putatunda S, Gorain M, Chakraborty A, Kundu GC, Das T, Sen PC. Cross-talk between ER stress and the MEK/ERK pathway potentiates apoptosis in human triple-negative breast carcinoma cells: Role of a dihydropyrimidone, Nifetepimine. J Biol Chem. (2015) 290(7):3936-49. (Impact Factor. 4.573)

2013 - 2014

  1. Mukherjee S, Mazumdar M, Chakraborty S, Manna A, Saha S, Khan P, Bhattacharjee P, Guha D, Adhikary A, Mukhjerjee S, Das T. Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop. Stem Cell Res Ther. (2014) 5(5):116. (Impact Factor. 3.37)
  2. Chakraborty S, Das K, Saha S, Mazumdar M, Manna A, Chakraborty S, Mukherjee S, Khan P, Adhikary A, Mohanty S, Chattopadhyay S, Biswas S, Sa G, Das T. Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone de-acetylation. J Biol Chem. (2014) 289(42):29074-85. (Impact Factor. 4.573)
  3. Adhikary A, Chakraborty S, Mazumdar M, Ghosh S, Mukherjee S, Manna A, Mohanty S, Nakka KK, Joshi S, De A, Chattopadhyay S, Sa G, Das T. Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of Slug transcription and inhibition of E-cadherin degradation: dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells. J. Biol Chem (2014) 289(37): 25431-25444. (Impact Factor. 4.573)
  4. Chakraborty S, Adhikary A, Mazumdar M, Mukherjee S, Bhattacharjee P, Guha D, Choudhuri T, Chattopadhyay S, Sa G, Sen A, Das T. Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. PLoS One. (2014) 9(6):e99743. (Impact Factor. 3.234)
  5. Chakraborty S, Mazumdar M, Mukherjee S, Bhattacharjee P, Adhikary A, Manna A, Chakraborty S, Khan P, Sen A, Das T. Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. FEBS Lett. (2014) 588(4):549-59. (Impact Factor. 3.169)
  6. Mohanty S, Saha S, Md S Hossain D, Adhikary A, Mukherjee S, Manna A, Chakraborty S, Mazumdar M, Ray P, Das K, Chakraborty J, Sa G and Das T. ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors Cell Death Dis. (2014) 5:e1021. (Impact Factor. 5.014)
  7. Mazumdar1 M*, Adhikary A*, Chakraborty S, Mukherjee S, Manna A, Saha S, Mohanty S, Dutta A, Bhattacharjee P, Ray P, Chattopadhyay S, Banerjee S, Chakraborty J, Ray A K, Sa G and Das T. Targeting RET to induce medullary thyroid cancer cell apoptosis: An antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways. Apoptosis (2013) 18(5):589-604. (Impact Factor. 3.614)
    *These two authors have contributed equally.
  8. Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, Dey S, Sa G, Das T, Chattopadhyay S, Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways J Nutr Biochem (2013) 24 (12):2040–2050. (Impact Factor. 4.592)
  9. Chatterjee S, Chakraborty P, Banerjee K, Sinha A, Adhikary A, Das T, Choudhuri SK. Selective induction of apoptosis in various cancer cells irrespective of drug sensitivity through a copper chelate, copper N-(2 hydroxy acetophenone) glycinate: crucial involvement of glutathione. Biometals. (2013) 26(3):517-534. (Impact Factor. 2.689)

2012 - 2013

  1. Ghosh S, Adhikary A, Chakraborty S, Nandi P, Mohanty S, Chakraborty S, Bhattacharjee P, Mukherjee S, Putatunda S, Chakraborty S, Chakraborty A, Sa G, Das T and Sen P.C. Nifetepimine, a dihydropyrimidone, ensures CD4+ T cell survival in tumor micro‐environment by maneuvering Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) J. Biol Chem (2012) 287,39: 32881–32896. (Impact Factor. 4.573)
  2. Saha S, Adhikary A, Bhattacharjee P, Das T and Sa G. Death by Design: WhereCurcumin Sensitizes Drugresistant Tumours. Anticancer Res (2012) 32 (7) 2567‐2584. (Impact Factor. 1.826)
  3. Dey Ghosh R, Chakraborty P, Banerjee K, Adhikary A, Sarkar A, Chatterjee, Das T, Choudhuri S K. The molecular interaction of a copper chelate with human P-glycoprotein. Mol Cell Biochem (2012) 364:309–320. (Impact Factor. 2.388)
  4. Chakraborty P, Chatterjee S, Ganguly A, Saha P, Adhikary A, Das T, Chatterjee M and Choudhuri S. Reprogramming of TAM toward proimmunogenic type through regulation of MAP kinases using a redox-active copper chelate. J Leukoc Biol (2012) 91:609-619. (Impact Factor. 4.304)
  5. Saha B*, Adhikary A*, Ray P, Saha S, Chakraborty S, Mohanty S, Das K, Mukherjee S, Majumder M, Lahiry L, Hossain DMS, Sa G and Das T. Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells. Oncogene (2012) 31, 173–186. (Impact Factor. 8.459)
    *These two authors have contributed equally.

2010 - 2011

  1. Mohanty S, Adhikary A, Chakrabarty S, Sa G and Das T. Curcumin: Operation 'p53 Hunt' to combat cancer: Theaflavins in action. Front. Biosci. (2011) S4, 300‐320. (Impact Factor. 2.484)
  2. Chakraborty J, Banerjee S, Ray P, Hossain S, Bhattacharyya S, Adhikary A, Chattopadhyay S, Das T and Sa G. Gain of cellular adaptation due to prolong p53 impairment leads to functional switch‐over from p53 to p73 during DNA damage in acute myeloid leukemia cells. J. Biol Chem (2010) 10.1074; 33104-33112. (Impact Factor. 4.573)
  3. Adhikary A, Mohanty S, Lahiry L, Hossain DMS, Chakraborty S and Das T. Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk. FEBS Lett (2010) 584:7-14. (Impact Factor. 3.169)
  4. Adhikary A, Mohanty S, Lahiry L, Hossain DMS, Chakraborty S and Das T. Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk. FEBS Lett (2010) 584:7-14. (Impact Factor. 3.169)

2009

  1. Chatterjee S, Mookerjee A, Mookerjee Basu J, Chakraborty P, Ganguly A, Adhikary A, Mukhopadhyay D, Ganguli S, Banerjee R, Ashraf M, Biswas J, Das P, Sa G, Chatterjee M, Das T, and Choudhuri S. A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells. Plos One (2009) 4(9): e7048. (Impact Factor. 3.234)

Patents

  1. "Hyaluronic acid-decorated Thymoquinone-loaded Pluronic® P123-F127mixed polymer nanoparticles as targeted therapy against Triple Negative Breast Cancer” Indian Patent Application number: 201831021395 A dated 7th June 2018. Online Publication Date: 19/10/2018.

Quick Links

Quick Links

Call Us Now

  • CRNN, University of Calcutta,
  • JD 2, Sector III, Salt Lake City,
  • Kolkata 700106, West Bengal, INDIA
  • Email: crnn@caluniv.ac.in
  • Phone: +91 33 2335 1063